A placebo-controlled study comparing the efficacy of intra-articular injections of hyaluronic acid and a novel hyaluronic acid-platelet-rich plasma conjugate in a canine model of osteoarthritis.
The purpose of this study was to assess the efficacy of intra-articular injection of hyaluronic acid (HA) and a novel, where the conjugate of HA with fibrinogen autologous be platelet rich plasma (HA-PRP) in a canine model of osteoarthritis (OA) METHOD : Twelve Donkey Serum beagle dogs underwent unilateral resection of the cranial cruciate ligament (CrCl) of the joint crippling. clinical signs and radiographic OA was confirmed in all dogs 8 weeks after CrCl resection and before treatment. The dogs were randomized into three groups: saline (n = 4), HA (n = 4), and HA-PRP (n = 4). Each dog receives intra-articular injections of each substance into the affected joint in a pre-determined point in time. The dogs were assessed for adverse events during 3 days after each injection and for lameness, pain, range of motion, kinetics, and radiographic OA severity before treatment and 3 months after injection. OA severity as determined by radiographic examination did not differ s...