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Assessment of the Efficacy of Platelet-Rich Plasma in the Treatment of Traumatic Canine Fractures.

Role of platelet rich plasma (PRP) to promote fracture healing has not been stated clearly. The aim of this prospective clinical study was to evaluate the effectiveness of plasma rich in growth factors (PRGF, derivate PRP) in the treatment of bone fracture occurs naturally in dogs. 

With the goal, sixty-five-dog with Goat Serum a radius / ulna or tibia / fracture of the fibula were randomly divided into two groups (PRGF and saline solution (SS) group) and examined at days 0, 7, 14, 21, 28, 35, 42, 49, 56, 60, 63, 70, 120, and 180.

 All fractures treated with external skeletal fixation, and pain is controlled with carprofen. Healing was evaluated by physical examination, limb function, radiographic, and by Likert-type questionnaires owner satisfaction. A more rapid healing of fractures observed in PRGF group, with a statistically significant difference against the SS. Swelling at the site of fracture was significantly greater at 14 and 28 days in animals injected with the PRGF, and pain on palpation found in the area in the 28th injection of PRGF in acute fractures accelerate bone healing.
Assessment of the Efficacy of Platelet-Rich Plasma in the Treatment of Traumatic Canine Fractures.


humanin Plasma as a prognostic biomarker for canine myxomatous mitral valve disease: comparison with plasma NT-roBNP.


myxomatous mitral valve disease (MMVD) is a common heart condition found in older dogs. The process of the disease can lead to heart failure (HF). In HF, an increase in reactive oxygen species (ROS) and abnormal mitochondrial activity, and apoptosis, have been reported. Humanin (HN) is a polypeptide having a cardioprotective effect against apoptosis and oxidative stress. 

The purpose of this study were (1) to investigate the potential role of plasma HN as cardiac biomarkers to predict disease progression MMVD, and (2) to https://gentaur.ch/ compare the plasma concentrations of HN plasma concentration of NT-pro BNP. Thirty-one dogs were included in this study. The dogs were separated into four groups: Group 1 is a healthy dog ​​(n = 8), Group 2 is MMVD class B (n = 8), group 3 is MMVD class C (n = 8), and Group 4 is MMVD class D (n = 7). 

All dogs were given a physical examination, chest radiography, echocardiography, and their blood samples were collected for hematology and blood chemistry analysis. HN plasma and plasma levels of NT-proBNP was also investigated.
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